The Capsid team develops algorithms and software to help study biological systems and phenomena from a structural point of view. In particular, the team aims to develop algorithms which can facilitate and improve the 3D modeling of large multi-component bio-molecular machines. While the team’s principal activity is algorithm and software development, it also tackles « real-world » biological problems through collaborations with the University of Lorraine and Nancy Hospital, and with other research teams from Inria, CNRS, INRA, INSERM, and international universities.
The team’s activities focus on two main themes:
- Computational modeling of protein-protein and protein-RNA interactions (docking, molecular dynamics simulations)
- Classifying and mining protein structures and protein interactions (knowledge discovery in biological databases).
The team is common (« Equipe Projet Commune ») to the Centre de Recherche Inria Nancy Grand-Est and the LORIA. Its activity in structural bioinformatics is supported by a research platform (MBI-DS4H) which is associated with the Institut Français de Bioinformatique.
The Capsid team was created in 2015 by Dr Dave Ritchie who passed away on sept 15, 2019. His open-mindedness and scientific contributions continue to inspire us. Download his HDR (Habilitation à Diriger les Recherches).
Structural bioinformatics; protein and RNA docking; protein interactions; biological data mining; molecular dynamics; virtual drug screening.